Spandan Critical Care & ICU

Microbiome in Critical Illness

Multiple factors can bring the microbiome out of balance in critically ill patients in the intensive care unit. These include antibiotic use, mechanical ventilation, changes in diet and inflammatory responses. The dysbiosis of the microbiome can alter immunological responses and could potentially have an impact on patient outcomes.

There are approximately 100 billion microorganisms in our body. The microbiome has a diverse role to play in the overall maintenance of human health and wellness. However, very little attention is paid to this microbial community. It is important to study and interpret the microbiome in critically ill patients as this can provide significant insight on how it can be manipulated to improve clinical outcomes.

The goal of addressing the microbiome in critically ill patients is to ensure that it does not transform from a health-inducing entity into a disease-promoting agent. Once we recognise the fact that the composition of the microbiome in critically ill patients evolves rapidly and can become significantly altered with the severity of illness, we will understand the importance of ensuring this does not happen. Multiple factors are at play, and that is why there is a need to apply effective therapeutic strategies for manipulating the microbiome in critical illness.

In this issue, our contributors discuss Microbiome in Critical Illness. Francesca Forfori and co-authors explore the many roles of gut microbiota and highlight the importance of targeting therapeutical interventions to restore, preserve and enrich its composition. Nathan Klingensmith and Craig Coopersmith discuss how critical illness alters the intestinal microbiome and how manipulating it could offer a potential treatment approach in ICU patients.

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